Michael McFadden was born in Upper Darby, Pennsylvania, the son of Maria, born to Italian immigrants, and J. Michael, of Irish descent. He had a younger sister, Rachel Janine, who passed away in 1994.

He took a circuitous route to the acting profession, attending The University Of The Arts in Philadelphia on a scholarship as an opera major before successfully auditioning for the school's theater program. Michael left U of A one year later to pursue a career in New York City. It was there that he met friend and teacher, William Hickey, the Academy Award nominated star of Prizzi's Honor, with whom he studied at HB Studio.

While paying the rent as a taxi driver, waiter, and bartender, he immersed himself in the theatre, playing roles that varied from MacDuff and Romeo at The Frog And Peach, a Shakespeare repertory company, to Victor in a musical adaptation of Frankenstein, and Stephen, in Israel Horovitz's “Line” at The Thirteenth Street Repertory Company.

Michael has co-starred on "Gotham" (2016), the HBO original series "The Deuce" (2017), and the Amazon original series, "The Tick" (2017). He starred alongside Ice-T in the feature film, “Bloodrunners”, released worldwide on March 7, 2017, which he co-wrote with director, Dan Lantz.